Opioids may be recommended as a second-line pharmacotherapy but have risks including overdose and death. Cannabis has been shown to be effective for treating nerve pain without the risk of fatal poisoning.
The Current State of Evidence and Recommendations for Research (2017) by National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During...
There is rising popularity of cannabis and CBD to treat a variety of health issues, however there is still much fear around its impact and potential dependencies. Here is the report from the World Health Organisation on drug dependence.
by Wen-Juan Huang, Wei-Wei Chen and Xia Zhang Depression and pain co-exist in the majority of patients and often contribute to high mortality. Most patients who suffer from the comorbid depression and pain are not responsive to pharmacological treatments that address either the pain or depression, exacerbating this comorbidity disorder. Cannabinoids present in marijuana are...
by Orrin Devinsky, Maria Roberta Cilio, Helen Cross, Javier Fernandez‐Ruiz, Jacqueline French, Charlotte Hill, Russell Katz, Russell Katz, Vincenzo Di Marzo, Didier Jutras‐Aswad, William George Notcutt, Jose Martinez‐Orgado, Philip J. Robson, Brian G. Rohrback, Elizabeth Thiele, Benjamin Whalley, Daniel Friedman. The antiepileptic mechanisms of CBD are not known, but may include effects on the equilibrative...
by Gregory T Carter, Simone P Javaher, Michael HV Nguyen, Sharon Garret & Beatriz H Carlini The field of pain medicine is at a crossroads given the epidemic of addiction and overdose deaths from prescription opioids. Cannabis and its active ingredients, cannabinoids, are a much safer therapeutic option. Despite being slowed by legal restrictions and...
by Mary Barna Bridgeman, PharmD, BCPS, BCGP and Daniel T. Abazia, PharmD, BCPS, CPE The purpose of this article is to review the historical significance of the use of medicinal cannabis and to discuss its pharmacology, pharmacokinetics, and select evidence on medicinal uses, as well as to describe the implications of evolving medicinal cannabis regulations and...
